DURAClone IM TCRs
Mature T cells express T cell receptors (TCRs) that enable low affinity-recognition of antigens bound to major histocompatibility complex (MHC) molecules. Two forms of TCRs are known either consisting of heterodimers of variable α and β protein chains or γ and δ protein chains. The proportion of these two subpopulations are considered important in immunity and tolerance with mechanisms still under investigation. The DURAClone IM TCRs panel allows for assessment of TCR αβ and TCR γδ protein chain expression and detection of Vδ1+ and Vδ2+ subsets among TCRγδ+ T cells. It utilizes dry reagent technology that confers workflow improvements.
- Combination of 9 markers in fluorochrome combinations that provide robust population identification, including CD3, CD4, CD8, CD45, HLA-DR, TCR αβ, TCR γδ, TCR Vδ1, TCR Vδ2
- Pre-formulated antibody panel in a unitized assay eliminating antibody cocktailing
- 25 tests per kit including 3 compensation kits with lot matched tandem dyes
For Research Use Only. Not for use in diagnostic procedures.
Features
Expert Panels
- Proven marker combination to identify the relative proportions of TCR types in the T cell compartment
- Open channels to add drop-in markers to modify for different research questions
- Designed for assay precision and lot-to-lot consistency
Efficiency
- Eliminate time spent in titrating different antibody lots
- Avoid waste that comes from preparing cocktail master mix
- Simplify inventory management
Consistency
- Unitized assays eliminate error prone pipetting steps
- Includes lot matched tandem dyes for compensation controls for improved accuracy
- Dry format maintains reagent performance better than liquid under stress conditions
Easy to Use
- Ready to use assay with verified panel design
- Includes sample preparation and staining procedure
- Streamlined workflow, just add sample, incubate, wash and acquire
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Technical Documents
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