DURAClone RE CLB
The DURAClone RE panels enable sensitive detection of rare abnormal cell populations in blood or bone marrow using carefully optimized and titrated antibody combinations. Mature human peripheral B cells (CD45+CD19+ lymphocytes) express high density levels of the antigens CD20, CD79b and CD81 on their surface. In contrast, the antigens CD5, CD43 and ROR1 are expressed at low density in a small fraction of these cells. Expression patterns involving high expression of CD5, CD43 and ROR1 accompanied by reduced expression of CD20, CD79b, and CD81 can be utilized to identify abnormal mature B cells even at very low frequencies.
- Combination of 8 markers for sensitivity detection of abnormal mature B cells, including CD5, CD19, CD20, CD43, CD45, CD79b, CD81, ROR1
- Pre-formulated antibody panel in a dry unitized assay eliminating antibody cocktailing
- 25 tests per kit including 3 compensation kits with lot matched tandem dyes
For Research Use Only. Not for use in diagnostic procedures.
Features
Expert Panels
- Proven marker combination to detect small populations of normal and abnormal mature B cells
- Open channels to add drop-in markers to modify for different research questions
- Designed for assay precision and lot-to-lot consistency
Efficiency
- Eliminate time spent in titrating different antibody lots
- Avoid waste that comes from preparing cocktail master mix
- Simplify inventory management
Consistency
- Unitized assays eliminate error prone pipetting steps
- Includes lot matched tandem dyes for compensation controls for improved accuracy
- Dry format maintains reagent performance better than liquid under stress conditions
Easy to Use
- Ready to use assay with verified panel design
- Includes sample preparation and staining procedure
- Streamlined workflow, just add sample, incubate, wash and acquire
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