TRBC1 Antibodies

The TCR constant β chain 1 or TRBC1 is randomly selected during T-cell development in the thymus. TRBC1 is a part of the TCRαβ-CD3 complex only expressed on mature αβ T-cells; γδ T-cells are inherently negative for TRBC1. TRBC1 is mainly localized on the cell surface but also detectable in the cytoplasm (Horna et al., 2022).

Anti-TRBC1 in combination with Anti-TRBC2 conjugates can be used for a low-cost, rapid, and specific T-cell clonality test using flow cytometry. TRBC1 and TRBC2 are mutually exclusive. Normal T-cell populations include a mix of the two, while clonal populations include only one.

For Research Use Only. Not for use in diagnostic procedures.