This site uses cookies and related technologies, as described in our privacy policy, for purposes that may include site operation, analytics, enhanced user experience, or advertising. You may choose to consent to our use of these technologies, or manage your own preferences.
Introducing the Next-Generation
Basophil Activation Test (BAT)
Introducing the Next-Generation
Basophil Activation Test (BAT)
Our new custom next-generation Basophil Activation Test (BAT) based on our award-winning solution can be provided through our Custom Design Service (CDS). You can choose the allergens and antibodies for your custom dry antibody panel. No antibody and no allergen pipetting needed!
Leveraging dry technology to overcome traditional BAT challenges
- Fostering standardization: Conjugated antibodies and allergens are pre-mixed at desired dose, and dried down together in a single tube. Negative and positive controls can be included.
- Straightforward: add your sample, vortex and acquire your data.
- Easy to use: no compensation, no centrifuge, compatible with any flow cytometer.
- Customizable: define your own combination of antibodies and allergens with specifications and format of your choice.
What is a Basophil Activation Test (BAT)?
BAT is a functional assay for measuring basophil activation in response to specific allergens or other stimuli.
Basophils play a critical role in allergies by releasing histamine and other mediators when activated. During a Basophil Activation Test a sample of blood is exposed to suspected allergens and then analyzed on a flow cytometer to identify the activation of basophils using conjugated antibodies specific to activation markers expressed on the surface of basophils.
However, due to the perceived complexity of the tools, BAT has not been widely adopted so far. Ready-to-use dry reagents can support driving adoption by being straightforward, standardized and easy to use, giving access to BAT insights even to non-expert laboratories.
BAT is minimally invasive and could potentially be complementary to traditional tools used in the study of allergies.
A promising outlook for BAT
Our next-generation BAT technology led to the solution being selected as the most promising approach to create an accurate, accessible, user-friendly test for the study of food allergies by FARE, the US leading non-profit organization engaged in food allergy advocacy.
Prepared BAT samples are stable for days
Published data* show that stained samples can remain stable at room temperature for up to 5 days. Even without flow cytometry expertise, labs can prepare samples on-site in dry DURAClone tubes and send them to a reference lab for analysis. This helps ensure reliable results without immediate processing or special storage conditions.
*A novel approach to the basophil activation test for characterizing peanut allergic patients in the clinical setting Agyemang A, Suprun M, Suarez-Farinas M, Boina F, et al., Allergy 2021, 76, 2257
For Research Use Only. Not for use in diagnostic procedures.
