Cell Line Development for Biologics

Automated Solutions for Cell Line Development

From producing cutting-edge vaccines to developing antibody drug conjugates to treat cancer, the use of cell lines to develop and produce drugs is changing all facets of the biopharma industry. Cell line development is no simple task. It’s a critical cog in the biologics production wheel.

Despite advances in technology, manual bottlenecks still plague this workflow. Putting a lifesaving biologic, such as a targeted monoclonal antibody, on the market requires years of drug discovery research, development, clinical trials and scaling up for commercialization. Beckman Coulter Life Sciences is more than an instrument solution provider.

Our experts in cell line development can help answer your questions and work with you on a customized solution that’ll transform your cell line development workflow into a nimble, efficient and results-driven enterprise.


VECTOR CONSTRUCTION

STABLE TRANSFECTION

SINGLE-CELL DEPOSITION AND MONOCLONALITY

CLONE SCREENING

CLONE STABILITY

MASTER CELL BANKING

Click on each step of the workflow to know more

VECTOR CONSTRUCTION

STABLE TRANSFECTION

SINGLE-CELL DEPOSITION AND MONOCLONALITY

CELL LINE OPTIMIZATION

CLONE STABILITY

MASTER CELL BANKING

Design and produce a vector for protein expression.

Biomek i-Series Automated Liquid Handler

Biomek i-Series Automated Liquid Handler

Echo Acoustic Liquid Handlers

Echo Acoustic Liquid Handlers

Transfect cells with a vector, integrating into genome.

Biomek i-Series Automated Liquid Handler

Biomek i-Series Automated Liquid Handler

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability Analyzer

CytoFLEX SRT Benchtop Cell Sorter

CytoFLEX SRT Benchtop Cell Sorter

CytoFLEX Flow Cytometer

CytoFLEX Flow Cytometer

Allegra V-15R benchtop centrifuge

Allegra V-15R benchtop centrifuge

Singly deposit clones into culture and image to verify monoclonality.

Biomek i-Series Automated Liquid Handler

Biomek i-Series Automated Liquid Handler

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability Analyzer

CytoFLEX SRT Benchtop Cell Sorter

CytoFLEX SRT Benchtop Cell Sorter

Test and select clones based on product analyses.

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability Analyzer

CytoFLEX Flow Cytometer

CytoFLEX Flow Cytometer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Valita Titer Assays for IgG Quantification

Valita Titer Assays for IgG Quantification

Optima AUC

Optima AUC

Cydem VT Automated Clone Screening System

Cydem VT Automated Clone Screening System

Study for stable production across many generations.

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Valita Titer Assays for IgG Quantification

Valita Titer Assays for IgG Quantification

Optima AUC

Optima Analytical Ultracentrifuge

Cryopreserve successful lines for future development.

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability Analyzer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Vi-CELL MetaFLEX Bioanalyte Analyzer

Allegra V-15R benchtop centrifuge

Allegra V-15R benchtop centrifuge


 

Learn More About Our Solutions For Cell Line Development

 

Learn more with our resources

Application Note

Cell Line Development – Hit Picking

Cell Line Development – Hit Picking

Application Note

Automating Cell Line Development

Automating Cell Line Development

Application Note

Automating Cell-Based Processes

Automating Cell-Based Processes

Application Note

Cell Line Development – Selection and Enrichment

Cell Line Development – Selection and Enrichment

Application Note

Cell Line Development – Limiting Dilution

Cell Line Development – Limiting Dilution

Application Note

Cell Line Development for Hybridoma

Cell Line Development for Hybridoma

Application Note

Automated determination of cell concentration and viability

Automated determination of cell concentration and viability

Brochure

Cydem VT Automated Clone Screening System

Cydem VT Automated Clone Screening System

 

Watch A Story About Developing Scalable, High-Yielding CHO Cell Lines

cell line development webinar by excellgene using the valita titer assay

Thanks in part to the Valita Titer assay, ExcellGene—a Swiss biologics CDMO—was able to develop scalable, high-yielding (4-8 g/L) Chinese hamster ovary (CHO) cell lines in just eight weeks.

Watch as ExcellGene’s Dr. Joeri Kint explains how being able to measure IgG directly in cell suspension and go straight from culture to plates and results is enabling them to rapidly select high-producing clones.

Watch Now

Process Development

Extracellular Vesicles

Future of Bioprocessing

Cell Line Development

ECHO is a trademark or registered trademark of Labcyte Inc. in the United States and other countries. Valita, Valita Titer and the ValitaCell logo are trademarks of ValitaCell Ltd. in the United States and other countries. Labcyte and ValitaCell are Beckman Coulter Companies.

For Research Use Only. Not for use in diagnostic procedures.


 

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