Automated Solutions for Cell Line Development
From producing cutting-edge vaccines to developing antibody drug conjugates to treat cancer, the use of cell lines to develop and produce drugs is changing all facets of the biopharma industry. Cell line development is no simple task. It’s a critical cog in the biologics production wheel.
Despite advances in technology, manual bottlenecks still plague this workflow. Putting a lifesaving biologic, such as a targeted monoclonal antibody, on the market requires years of drug discovery research, development, clinical trials and scaling up for commercialization. Beckman Coulter Life Sciences is more than an instrument solution provider.
Our experts in cell line development can help answer your questions and work with you on a customized solution that’ll transform your cell line development workflow into a nimble, efficient and results-driven enterprise.
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VECTOR CONSTRUCTION |
STABLE TRANSFECTION |
SINGLE-CELL
DEPOSITION |
CELL LINE |
CLONE STABILITY |
MASTER CELL BANKING |
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| Design and produce a vector for protein expression. | Transfect cells with a vector, integrating into genome. | Singly deposit clones into culture and image to verify monoclonality. | Test and select clones based on product analyses. | Study for stable production across many generations. | Cryopreserve successful lines for future development. |
Learn More About Our Solutions For Cell Line Development
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Watch A Story About Developing Scalable, High-Yielding CHO Cell Lines
Thanks in part to the Valita Titer assay, ExcellGene—a Swiss biologics CDMO—was able to develop scalable, high-yielding (4-8 g/L) Chinese hamster ovary (CHO) cell lines in just eight weeks.
Watch as ExcellGene’s Dr. Joeri Kint explains how being able to measure IgG directly in cell suspension and go straight from culture to plates and results is enabling them to rapidly select high-producing clones.
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