How is the sedimentation coefficient determined?

If you know the particle velocity (υ), the angular velocity (ω), and the radius from the axis of rotation (r), you can calculate the sedimentation coefficient (s).

Per the left side of the equation, this value is proportional to molecular weight (M) multiplied by buoyancy factor (1-v p and inversely proportional to the frictional coefficient. Large values of S (faster sedimentation rate) correspond to larger molecular weight.

Sedimentation coefficient determination

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