How can small molecule drugs help boost the immune system?

Small molecule drugs target immune cell protein-protein interactions to modulate their function and counteract pathological mechanisms. Small molecule drug-based preclinical and clinical studies are an active area of research in cancer immunotherapy. This includes inhibitors for the CBP/EP300 bromodomain, the deubiquitylase USP7, as well as the T-cell response regulating proteins IDO1 and TDO.¹

Reference:
1. Y. Zheng, et al., "Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors," ACS Nano 11(3):3089-3100, 2017.

Stay up to date with our newsletter

Receive timely updates on your favorite topics from the experts at Beckman Coulter Life Sciences

© 2000-2024 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. All other trademarks are the property of their respective owners.

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES. PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS The listed regulatory status for products correspond to one of the below: IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use." ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagent. Analytical and performance characteristics are not established." CE-IVD, CE: Products intended for in vitro diagnostic use and conforming to the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746. (Note: Devices may be CE marked to other directives.) RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures." LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only." No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.