CD65 Antibodies

The CD65 antigen is analogous to the carbohydrate structure(s) recognized by CD15 antibodies. CD65 is a type II chain fucoganglioside involving the oligosaccharide sequence: Galβ1-4GlcNacβ1-3Galβ1-4GlcNac(Fucα1-3)β1-R. CD65 has been suggested as the CD62L ligand, and it has been hypothesized to be involved in the extra vascular infiltration. CD65 is normally expressed on neutrophils, eosinophils, and basophils, on a monocyte subset and on a fraction of CD56bright NK cells. It is not expressed on lymphocytes. CD65 is also found on the membrane of adipocytes and on thymic epithelium but it is not expressed by mastocytes. In myeloid ontogenesis, CD65 seems to be expressed later than myeloperoxidase (MPO).