IgE (Dε2) Antibodies

The anti-IgE mAb binds to circulating IgE as well as to IgE antibodies bound to the low affinity receptor FcεRII (expressed mainly on eosinophils, B lymphocytes), or to the high affinity receptor FcεRI (expressed on mast cells, basophils, monocytes and monocytes-derived cells). The anti-IgE antibody induces the histamine release from basophils. However, it is known in the literature information that basophils from 10% to 20% of donors completely fail to release histamine in response to anti-IgE, designated anti-IgE "non releasers".