CD26 Antibodies

The CD26 antigen is the dipeptidylpeptidase IV ectoenzyme (DPPIV). It is a single-chain glycoprotein with a molecular weight of 110 kDa. It binds to adenosine deaminase protein (ADA). CD26 is a functional collagen receptor. CD26 provides an alternative activation pathway for T lymphocytes in which the CD3ζ (TCRζ chain) is required for CD26‑mediated signaling. The expression of CD26 is found on resting T cells and is increased on activated T lymphocytes, B lymphocytes, macrophages and NK cells. In a study using this antibody, it has been suggested that CD26 is involved as a cofactor of CD4 in the mechanism of triggering apoptosis. Another study showed the expression of CD26 in human kidney and on lymphocytes and macrophages of specific skin biopsies.