Automated Solutions for Cell Line Development
Your Guide to Workflow Intelligence
Product Solutions
Biomek i7 Automated Workstation
Improve procedural ELISA, achieve single cell suspension reliably, simplify transfection optimization, and adapt basic cell culture workflows.
- Extend production scale and centralize operations
- Leverage dual-arm pipetting
- Flexibility with reagent and media mixing, and cell passaging and plating
- Improve efficiency by directly integrating required components
- Simplify serial dilutions with built-in spanning transfer system
- Improve analysis efficiency with sample and data tracking*
- Take control of multi-day planning*
- Monitor progress with platform status light
- Remote system monitoring using on-deck cameras
*Possible through optional software packages DART and SAMI.
Orbital Shaker
Promote cell health with user-definable and reliable agitation of microplates, cultured cells, or general vortexing.- Smooth and continuous motion, enabling nutrient diffusion without splashing
- Timed oribtal and pulse shaking
- Ramped acceleration/deceleration
- Shaking speed ranges from 100 rpm to 1800 rpm
- Space saving
- Easily integrated with Biomek i7
- Increases experimental flexibility
Reagent Dispensers
Accelerate assay-specific or maintenance laboratory protocols with automated, precise dispensing. Ensure the accuracy of reagent dispense volumes.- Simplify workflows
- Dispense a wide range of volumes
- Minimize contamination
- Interchangeable dispensing heads available
- Increase accuracy
- Superior mixing
- Reduce air bubble formation
- Integrates with Biomek i7
- Flexibility to configure reagent containers of wide-ranging volumes
Automated Labware Positioners (ALPs)
Workstation-integrated and interchangeable components that perform specific tasks. ALPs make it possible to configure the platform for accommodation of a wide range of applications.Peltier
- Shaking model shakes microplates at speeds ranging from 100 rpm to 1400 rpm
- Temperature control capable
Tilting ALP
- Controlled and gentle media exchange
- Media is removed from edge of well without disturbing adherent cells
Incubator
An incubator provides a consistent environment for the housing of growing cell cultures and for the temporary incubation of cells underdoing experimental assays.- Temperature can range from 4° C to 70° C, with a relative high humidity (RH) of up to 98% stable CO2 conditions, and shaking
- Mammalian cell conditions: 37° C, 95% RH, and 5% CO2
- A Biomek i7 integration with an incubator eliminates recovery loss and reduces assay variance
- Increase throughput
- Streamline long-term cell culture processes
- Eliminate manual, repeated accessing of cells
Vi-CELL
Eliminate human error and user bias when counting cells and determining viability.- Automated solution for Trypan Blue viability assays
- Analyze mammalian, insect, and yeast cell types (2–70 microns)
- Clumpy samples can be differentiated in number and viability
- Quickly and reliably assess cell shape, size, growth rate, and doubling time
- Enhance statistical reliability
- Convenient reagent kit, concentration control, and sample cups
- Viable cells are outlined in green and nonviable in red:
CloneSelect™ Imager
Rapidly and objectively monitor cell growth, verify cell line monoclonality, and normalize measurements specific to cell productivity.
- Ultra-fast benchtop imaging system for:
- Confluence measurement
- Growth curve generation
- Cell number estimation
- Monoclonality verification
- Colony forming assays
- Cytotoxicity assays
- Cell migration assays
- Consistent results in less time
- Saves all images and generated data
- Integrates with Biomek i7 workstation
“CloneSelect Imager has become an essential system for verification of monoclonality within our cell line development workflow.”
− Dr. Howard Clarke, Process Development, CMC ICOS Biologics Inc., USA
Octet® Systems
Comprehensively characterize and optimize for cell clone lead(s), then, accurately measure target protein kinetics and concentration.
- Label-free biophysical characterization for various stages of cell line development
- Screen during clone selection to quickly rank by titer or off-rates
- Reduce sample prep time by assaying proteins directly in crude mixtures
- Measure specific binding interactions – determine affinity constants, epitope binning
- Complete solution for label-free protein kinetics and quantitation
- Ligand capture surfaces include antibodies, recombinant proteins, DNA, RNA, and virus-like particles
- ELISA replacement offering increased productivity and accuracy, with off-the-shelf kits for Host Cell Protein and Residual Protein A impurity detection
Robotic Arm
Offers dependable precision and flexibility that not only increases useable workspace, but reliably operates around the clock to eliminate human variability.
- Multiple axis points can reach peripheral equipment
- Walk away capability increases personnel productivity
- Accelerates time to results
- Enhance data reproducibility
- Improve laboratory ergonomics
- Integrates with Biomek i7
Capper/Decapper
Hands-free automated capping and decapping technology ensures sample protection, wholeness, and quality.
- Cap tubes to optimal torque
- Reliably increase throughput
- Improve laboratory ergonomics
- Benchtop or integrated use
- Internal controls prevent contamination and debris introduction
Robotic Shuttle
Controlled robotic plate management with a customizable conveyor track assists with handling consistency and eliminates human-induced accidents.
- Conveyor transports plates from location the Biomek deck to off deck components within the workstation
- Allows for simultaneous transports on and off deck for maximum efficiency
- Streamlines workflow for maximum productivity
Avanti JXN
High-Speed Centrifuge
Enhance isolation and purification workflows for a variety of bioproduction needs.
- Friction reduction system (FRS) for quicker, quieter, and cooler runs
- Shorter cycle times with high-torque and switched reluctance (SR) drive cycle
- Remote run setup and monitoring
- Hands-free door operation
- Track and control usage and samples
- Efficient, safe workflow matches industry compliance
Workflow Solutions
Learn about the solutions for each critical step of the process of developing a mammalian cell line for recombinant protein manufacturing using a methotrexate (MTX) amplification system, one of many integrated transfection methods by Beckman Coulter.
Automation can increase efficiency and consistency in selecting high producing cells with desired Critical Quality Attributes.
Cell Line Engineering
Optimal host cell transfection is dependent on cell health, degree of confluency, DNA quality and quantity, number of passages, contamination, and transfection reagent or method. OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Preparation of transfection reagents, addition of expression plasmid and transfection reagents
- Cell plating, handling, and maintenance minimize human error, enhancing reproducibility and enabling continuous production
Vi-CELL XR Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Octet® Systems
- Measure desired protein concentration
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Robotic Arm
- Moves plates between workstation and Octet/ analyzer
Cell Line Characterization
Select colonies by sub-cloning, which includes performing multiple rounds of serial dilution to identify the most stable and highest-producing single cell clone. This step is labor intensive and requires weeks to complete. OUR SOLUTIONS:
CloneSelect™ Imager
- Verify monoclonality
- Optimize and monitor clonal outgrowth
Octet® Systems
- Measure desired protein concentration
Biomek i7 Automated Workstation
- Cell-plating, handling, maintenance, and hitpicking
Automated Labware Positioners (ALPs)
- Perform application-specific or general tasks to expedite protocols
Reagent Dispenser
- Configure to dispense reagents from different containers and wide-ranging volumes
Robotic Arm
- Moves plates to/from workstation, incubator*, CloneSelect and Octet analyzers
Cell Line Characterization
Expand the clone producing your desired protein to begin the process development and optimization stage. Certifying clone productivity and quality is fundamental to efficient cell line scale up. Maintaining cell culture health and stable production are common pitfalls during this step. OUR SOLUTIONS:
Octet® Systems
- Characterize and measure protein productivity (e.g., concentration, kinetics, affinity)
Vi-CELL Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Biomek i7 Automated Workstation
- Hit picking and seeding
Robotic Arm
- Moves plates to/from workstation and Octet analyzer
Robotic Shuttle
- Conveyor track eliminates human-induced mishaps during transport
- Speed and acceleration can be controlled to prevent splashing in larger-well plates
Avanti JXN High-Speed Centrifuge
- Isolate and purify products reliably and efficiently
Process Development
As you scale up, media optimization will enable maximize protein production. An ideal approach is using a factorial design of experiment (DOE), where a variety of media components are tested at different concentrations in combination with one another. Automation of DOE eliminates any sample preparation beyond an optional dilution step and the high throughput models can process up to 96 samples simultaneously. OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Tight control of media dispensing volumes
- Gentle cell handling through controlled speed prevents cell shearing and damage
- DOE optimization with multi-channel selection tip
Octet® Systems
- Measure titer
- Biosensors for quick screening
CloneSelect™ Imager
- Monitor cell growth
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Biomek Automated Workstations are not intended or validated for use in the diagnosis of disease or other conditions. Beckman Coulter Life Sciences genomic reagent kits are for research US only.
Helpful Links
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阅读材料
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应用手册
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- Automated Cord Blood Cell Viability and Concentration Measurements Using the Vi‑CELL XR
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- Automating Cell-Based Processes
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- CytoFLEX
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- Detecting Moisture in Hydraulic Fluid, Oil and Fuels
- Detection of foreign matter in plating solution using Multisizer4e
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- dsDNA Quantification with the Echo 525 Liquid Handler for Miniaturized Reaction Volumes, Reduced Sample Input, and Cost Savings
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- 将 CytoFLEX S 流式细胞仪上设计的面板迁移至 CytoFLEX SRTl流式分选仪
- Miniaturization of an Epigenetic AlphaLISA Assay with the Echo Liquid Handler and the BMG LABTECH PHERAstar FS
- Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 555 Liquid Handler
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- Miniaturized Gene Expression in as Little as 250 nL
- Miniaturized Genotyping Reactions Using the Echo Liquid Handler
- Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
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- Optimized NGS Library Preparation with Acoustic Liquid Handling
- Astrios和CytoFLEX SRT流式分选仪的孔板分选速度比较
- Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Using the Echo Liquid Handler
- Purifying viral vector with VTi 90 rotor and CsCl DGUC
- Robust and High-Throughput SARS-CoV-2 Viral RNA Detection, Research, and Sequencing Using RNAdvance Viral and the OT-2 Platform
- 用CytoFLEX SRT细胞分选仪进行单细胞分选
- 用CytoFLEX SRT分选稀有E-SLAM造血干细胞及其后续培养
- Utilization of the MicroClime Environmental Lid to Reduce Edge Effects in a Cell-based Proliferation Assay
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- Accurately measures fine bubble size and particle count
- Adaptive Laboratory Evolution of Pseudomonas putida in the RoboLector
- Adjustment of the pH control settings in the BioLector® XT
- Aerobic cultivation of high-oxygen-demanding microorganisms in the BioLector XT microbioreactor
- An Analytical Revolution: Introducing the Next Generation Optima AUC
- Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor
- 使用 Multisizer 4e 库尔特颗粒计数及粒度分析仪监测贻贝/软体动物的繁殖
- Assay Assembly for Miniaturized Quantitative PCR in a 384-well Format Using the Echo Liquid Handler
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Automated Transfection Methods
- Automating a Linear Density Gradient for Purification of a Protein:Ligand Complex
- Automating Bradford Assays
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
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- Biomek基因组样品制备自动化解决方案加速研究进程
- Biomek i-Series Automated AmpliSeq for Illumina® Library Prep Kit
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- Biomek i-Series Automated Beckman Coulter Agencourt RNAdvance Cell
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- Biomek i-Series Automated Illumina Nextera DNA Flex Library Prep Kit
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- Biomek i-Series Automated Illumina TruSeq DNA PCR-Free Library Prep Kit
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- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Get Control in GMP Environments
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彩页
- Access Single Robot System——合成生物学工作流利器
- Automated Solutions for Cell Line Development
- Automated Solutions for ELISA
- Echo Acoustic Liquid Handling for Synthetic Biology
- HIAC 8011+ Liquid Particle Counting Systems
- HIAC 9703+ Sub-Visible Particulate Testing
- LS 13 320 XR - Laser Diffraction Particle Size Analyzer
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案例分析
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- DNA Extraction from FFPE Tissue
- English Safety Seminar
- Equipment Management
- Exosome Purification Separation
- Fast, Cost-Effective and High-Throughput Solutions for DNA Assembly
- Future of Fishing Immune Research
- Hematopoietic Tumor Cells
- High-throughput next-generation DNA sequencing of SARS-CoV-2 enabled by the Echo 525 Liquid Handler
- Hiroshima Genbaku HP Hematopoietic Tumor Testing
- iPS Cell Research
- Leveraging acoustic and tip-based liquid handling to increase throughput of SARS-CoV-2 genome sequencing
- Membrane Protein Purification X Ray Crystallography
- Organelles Simple Fractionation
- Particle Interaction
- Quality evaluation of gene therapy vector
- Retinal Cell Regeneration
- Sedimentary Geology
- Severe Liver Disease Treatment
- Tierra Biosciences reveals major molecular discovery
- Treating Cirrhosis
- University Equipment Management
- Fundamentals of Ultracentrifugal Virus Purification
- 产品目录
- 单页
-
专家访谈
- Background and Current Status of the Introduction of Flow Cytometers
- Benefits-of-the-coulter-principle-in-the-manufacturing-for-ips-cell-derived-natural-killer-cells
- Central Diagnosis in the Treatment of Childhood Leukemia 1
- Central Diagnosis in the Treatment of Childhood Leukemia 2
- Challenges-in-viability-cell-counting
- Contribution of Cytobank to 1-cell analysis of the cancer microenvironment
- Development of technology for social implementation of synthetic biology
- Flow Cytometry Testing in Hospital Laboratories
- Fundamentals of Ultracentrifugal Virus Purification
- The MET ONE 3400+ Automates Routine Environmental Monitoring for GMP Cleanroom Compliance
- Tumor Suppressor Gene p53 research and DNA Cleanup Process
- Fundamentals of Ultracentrifugal Virus Purification
- Dr Yabui UCF Lecture
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主题报告
- Applications of Ultracentrifugation in Purification and Characterization of Biomolecules
- Automating Genomic DNA Extraction from Whole Blood and Serum with GenFind V3 on the Biomek i7 Hybrid Genomic Workstation
- ABRF 2019: Automated Genomic DNA Extraction from Large Volume Whole Blood
- Automated library preparation for the MCI Advantage Cancer Panel at Miami Cancer Institute utilizing the Beckman Coulter Biomek i5 Span-8 NGS Workstation
- Automating Cell Line Development for Biologics
- Cell-Line Engeneering
- Characterizing the Light-Scatter Sensitivity of the CytoFLEX Flow Cytometer
- AACR 2019: Isolation and Separation of DNA and RNA from a Single Tissue or Cell Culture Sample
- Mastering Cell Counting
- Preparing a CytoFLEX for Nanoscale Flow Cytometry
- A Prototype CytoFLEX for High-Sensitivity, Multiparametric Nanoparticle Analysis
- ABRF 2019: Simultaneous DNA and RNA Extraction from Formalin-Fixed Paraffin Embedded (FFPE) Tissue
- Quantification of AAV Capsid Loading Fractions: A Comparative Study
- Using Standardized Dry Antibody Panels for Flow Cytometry in Response to SARS-CoV2 Infection
- 产品说明书
- 实验步骤
-
白皮书
- Centrifugation is a complete workflow solution for protein purification and protein aggregation quantification
- AUC Insights - Analysis of Protein-Protein-Interactions by Analytical Ultracentrifugation
- A General Guide to Lipid Nanoparticles
- Addressing issues in purification and QC of Viral Vectors
- GMP Cleanrooms Classification and Routine Environmental Monitoring
- Purification of Biomolecules by DGUC
- AUC Insights - Assessing the quality of adeno-associated virus gene therapy vectors by sedimentation velocity analysis
- AUC Insights - Sample concentration in the Analytical Ultracentrifuge AUC and the relevance of AUC data for the mass of complexes, aggregation content and association constants
- Analyzing Biological Systems with Flow Cytometry
- 亚可见颗粒物检测新进展：USP <1788>的最新修订
- Changes to USP <643> Total Organic Carbon
- Characterization of RNAdvance Viral XP RNA Extraction Kit using AccuPlex™ SARS–CoV–2 Reference Material Kit
- CytoFLEX Platform Flow Cytometers with IR Laser Configurations: Considerations for Red Emitting Dyes
- Evaluation of the Analytical Performance of the AQUIOS CL Flow Cytometer in a Multi-Center Study
- Simultaneous Isolation and Parallel Analysis of gDNA and total RNA for Gene Therapy
- Hydraulic Particle Counter Sample Preparation
- Inactivation of COVID–19 Disease Virus SARS–CoV–2 with Beckman Coulter Viral RNA Extraction Lysis Buffers
- Tips for Cell Sorting
- IVD-R Annex I Global Safety and Performances Requirements
- Liquid Biopsy Cancer Biomarkers – Current Status, Future Directions
- MET ONE 3400+ IT Implementation Guide
- Reproducibility in Flow Cytometry
- SuperNova v428: New Bright Polymer Dye for Flow Cytometry
- SuperNova v428: New Bright Polymer Dye for Flow Cytometry
- Japan Document
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应用手册
